MolNFT v1 · #157391 · protein
Crystal structure of human sting (G230A, H232R, R293Q) in complex with compound 18
6MXE: “Crystal structure of human sting (G230A, H232R, R293Q) in complex with compound 18”. X-ray diffraction, 2 ligands (K5S, CA). MolNFT v1 #157391 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MXE
- Type
- protein
- Length
- 333 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q86WV6
- Ligands
- K5S, CA
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 164 | — | Q86WV6 |
| B | — | protein | 169 | — | Q86WV6 |
Ligands and binding sites
- K5S · [(3S,4S)-2-(4-tert-butyl-3-chlorophenyl)-3-(2,3-dihydro-1,4-benzodioxin-6-yl)-7-fluoro-1-oxo-1,2,3,4-tetrahydroisoquinolin-4-yl]acetic acid · ligand · 2 copies · chains A, B
- CA · Calcium ion · metal · 2 copies · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6MXE · Crystal structure of human STING (G230A, H232R, R293Q) in complex with Compound 18 · the same entry in another collection · chain A against A, TM-score 1.00
- Q86WV6 · AlphaFold monomer V2.0 prediction for stimulator of interferon genes protein (Q86WV6) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86WV6
- Elsewhere: RCSB PDB 6MXE · PDBe 6MXE · UniProt Q86WV6
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