MolNFT v1 · #157315 · protein
NMR structure of the cntnc-ctni chimera bound to calcium desensitizer W7
6MV3 · Troponin C, slow skeletal and cardiac MUSCLES,TROPONIN I…: “NMR structure of the cntnc-ctni chimera bound to calcium desensitizer W7”. Solution nmr, 2 ligands (WW7, CA), 2 pockets (best druggability 0.70). MolNFT v1 #157315 on…
- PDB
- 6MV3
- Type
- protein
- Length
- 125 residues
- Chains
- 1
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Troponin C, slow skeletal and cardiac MUSCLES,TROPONIN I, cardiac muscle chimera
- UniProt
- P63316, P19429
- Ligands
- WW7, CA
- Pockets
- 2 · best druggability 0.70
Structure
solution nmr · 1 distinct chain · 52% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Troponin C, slow skeletal and cardiac MUSCLES,TROPONIN I, cardiac muscle chimera | protein | 125 | 52% helix, 2% strand | P63316, P19429 |
Ligands and binding sites
- WW7 · N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide · ligand · chains A
- CA · Calcium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 220 | 0.70 | 0.86 | 33 | WW7 |
| 2 | 55 | 0.28 | 0.74 | 15 | empty |
Compared structures
- 6MV3 · NMR structure of the cNTnC-cTnI chimera bound to calcium desensitizer W7 · the same entry in another collection · chain A against A, TM-score 1.00
- P63316 · AlphaFold monomer V2.0 prediction for troponin C, slow skeletal and cardiac muscles… · a predicted model of the same protein · chain A against A, TM-score 0.66
- P19429 · AlphaFold monomer V2.0 prediction for troponin I, cardiac muscle (P19429) · a predicted model of the same protein · chain A against A, TM-score 0.22
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63316
- Every structure of UniProt P19429
- Elsewhere: RCSB PDB 6MV3 · PDBe 6MV3 · UniProt P63316 · UniProt P19429
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