MolNFT v1 · #156776 · protein
Crystal structure determination of HUMAN/PORCINE chimera coagulation factor VIII
6MF0: “Crystal structure determination of HUMAN/PORCINE chimera coagulation factor VIII”. X-ray diffraction, 7 ligands (NAG, MAN, BMA). MolNFT v1 #156776 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6MF0
- Type
- protein
- Length
- 2,503 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P12263, P00451
- Ligands
- NAG, MAN, BMA, FUC, CA, ZN, CU1
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 1256 | — | P12263, P00451 |
| B | — | protein | 1247 | — | P12263, P00451 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 13 copies · chains A, B
- MAN · alpha-D-mannopyranose · sugar · 11 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar · 6 copies · chains B
- FUC · alpha-L-fucopyranose · sugar
- CA · Calcium ion · metal · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- CU1 · Copper (I) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6MF0 · Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII · the same entry in another collection · chain A against A, TM-score 1.00
- P12263 · AlphaFold monomer V2.0 prediction for coagulation factor VIII (P12263) · a predicted model of the same protein · chain A against A, TM-score 0.99
- P00451 · AlphaFold monomer V2.0 prediction for coagulation factor VIII (P00451) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12263
- Every structure of UniProt P00451
- Elsewhere: RCSB PDB 6MF0 · PDBe 6MF0 · UniProt P12263 · UniProt P00451
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