UniProt P00451
Coagulation factor VIII (P00451)
Coagulation factor VIII (UniProt P00451): 41 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 75 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P00451
- Protein
- Coagulation factor VIII
- Experimental structures
- 41
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 75 · 5 records with a druggable one
Structures
42 records of P00451 in the MolNFT archive: 41 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CFG | Membrane-binding peptide from the C2 domain of factor VIII forms an amphipathic structure as… | solution nmr | A | — | — |
| 1CFG | Membrane-binding peptide from the C2 domain of factor VIII forms an amphipathic structure as… | solution nmr | A | — | — |
| 1D7P | Crystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A | x-ray diffraction | M | — | — |
| 1D7P | Crystal structure of the C2 domain of human factor VIII at 1.5 a resolution at 1.5 a | x-ray diffraction | M | — | — |
| 1FAC | Coagulation factor VIII, NMR, 1 structure | solution nmr | A | — | — |
| 1FAC | Coagulation factor VIII, NMR, 1 structure | solution nmr | A | — | — |
| 1IQD | Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab. | x-ray diffraction | C | — | — |
| 1IQD | Human factor VIII C2 domain complexed to human monoclonal BO2C11 Fab. | x-ray diffraction | C | — | — |
| 2R7E | Crystal Structure Analysis of Coagulation Factor VIII | x-ray diffraction | A, B | — | — |
| 2R7E | Crystal structure analysis of coagulation factor VIII | x-ray diffraction | A, B | — | — |
| 3CDZ | Crystal structure of human factor VIII | x-ray diffraction | A, B | — | — |
| 3CDZ | Crystal structure of human factor VIII | x-ray diffraction | A, B | — | — |
| 3HNB | Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure… | x-ray diffraction | M | — | — |
| 3HNB | Factor VIII TRP2313-HIS2315 segment is involved in membrane binding as shown by crystal structure… | x-ray diffraction | M | — | — |
| 3HNY | Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure… | x-ray diffraction | M | — | — |
| 3HNY | Factor VIII TRP2313-HIS2315 segment is involved in membrane binding as shown by crystal structure… | x-ray diffraction | M | — | — |
| 3HOB | Factor VIII Trp2313-His2315 segment is involved in membrane binding as shown by crystal structure… | x-ray diffraction | M, A | — | — |
| 3HOB | Factor VIII TRP2313-HIS2315 segment is involved in membrane binding as shown by crystal structure… | x-ray diffraction | M, A | — | — |
| 3J2Q | Model of membrane-bound factor VIII organized in 2D crystals | electron crystallography | A, B | — | — |
| 3J2Q | Model of membrane-bound factor VIII organized in 2D crystals | electron crystallography | A, B | — | — |
| 3J2S | Membrane-bound factor VIII light chain | electron microscopy | B | — | — |
| 3J2S | Membrane-bound factor VIII light chain | electron microscopy | B | — | — |
| 4BDV | Crystal structure of a truncated B-domain human factor VIII | x-ray diffraction | A, B | — | — |
| 4BDV | Crystal structure of a truncated B-domain human factor VIII | x-ray diffraction | A, B | — | — |
| 4KI5 | Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory… | x-ray diffraction | M | — | — |
| 4KI5 | Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory… | x-ray diffraction | M | — | — |
| 4PT6 | The discobody: an engineered discoidin domain from factor VIII that binds v 3 integrin with… | x-ray diffraction | A, B | — | — |
| 4PT6 | The discobody: an engineered discoidin domain from factor VIII that binds V 3 integrin with… | x-ray diffraction | A, B | — | — |
| 4XZU | Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody | x-ray diffraction | M, G | MG | 6 (best 0.79) |
| 4XZU | Crystal structure of the human factor VIII C2 domain in complex with murine 3E6 inhibitory antibody | x-ray diffraction | M, G | — | — |
| 5K8D | Crystal structure of rFVIIIFc | x-ray diffraction | A, B | NAG, MAN, CA, CU | 20 (best 0.85) |
| 5K8D | Crystal structure of rfviiifc | x-ray diffraction | A, B | NAG, CA, CU | — |
| 6MF0 | Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII | x-ray diffraction | A, B | NAG, MAN, BMA, CA, ZN, CU1 | — |
| 6MF0 | Crystal structure determination of HUMAN/PORCINE chimera coagulation factor VIII | x-ray diffraction | A, B | NAG, MAN, BMA, CA, ZN, CU1 | — |
| 6MF2 | Improved Model of Human Coagulation Factor VIII | x-ray diffraction | A | NAG, CA, ZN, CU1 | — |
| 6MF2 | Improved model of human coagulation factor VIII | x-ray diffraction | A | NAG, CA, ZN, CU1 | — |
| 7K66 | Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody… | x-ray diffraction | A | NAG, MAN, CU, CA, ZN | 15 (best 0.86) |
| 7K66 | Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody… | x-ray diffraction | A | NAG, MAN, CU, CA, ZN | — |
| 7KBT | Factor VIII in complex with the anti-C2 domain antibody, G99 | x-ray diffraction | A | NAG, CU, ZN, CA | 18 (best 0.83) |
| 7KBT | Factor VIII in complex with the anti-C2 domain antibody, G99 | x-ray diffraction | A | NAG, CU, ZN, CA | — |
| 8G6I | Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor | electron microscopy | A | NAG | 16 (best 0.89) |
| P00451 | AlphaFold monomer V2.0 prediction for coagulation factor VIII (P00451) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 11 records
- CA · Calcium ion · in 10 records
- ZN · Zinc ion · in 8 records
- CU · Copper (II) ion · in 6 records
- MAN · alpha-D-mannopyranose · in 5 records
- CU1 · Copper (I) ion · in 4 records
- BMA · beta-D-mannopyranose · in 2 records
- MG · Magnesium ion · in 1 record
Experiment against prediction
- 4XZU chain M against the predicted model P00451: TM-score 0.99, RMSD 0.41 Å
- 4XZU chain M against the predicted model P00451: TM-score 0.99, RMSD 0.41 Å
- 4KI5 chain M against the predicted model P00451: TM-score 0.99, RMSD 0.41 Å
- 4KI5 chain M against the predicted model P00451: TM-score 0.99, RMSD 0.41 Å
- 3HOB chain M against the predicted model P00451: TM-score 0.99, RMSD 0.42 Å
- 3HOB chain M against the predicted model P00451: TM-score 0.99, RMSD 0.42 Å
- 3HOB chain A against the predicted model P00451: TM-score 0.99, RMSD 0.50 Å
- 3HOB chain A against the predicted model P00451: TM-score 0.99, RMSD 0.50 Å
- 6MF0 chain A against the predicted model P12263: TM-score 0.99, RMSD 1.21 Å
- 6MF0 chain A against the predicted model P12263: TM-score 0.99, RMSD 1.21 Å
Elsewhere
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