UniProt P12263
Coagulation factor VIII (P12263)
Coagulation factor VIII (UniProt P12263): 10 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 49 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P12263
- Protein
- Coagulation factor VIII
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 49 · 3 records with a druggable one
Structures
11 records of P12263 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4MO3 | Crystal Structure of Porcine C2 Domain of Blood Coagulation Factor VIII | x-ray diffraction | M | — | — |
| 4MO3 | Crystal structure of porcine C2 domain of blood coagulation factor VIII | x-ray diffraction | M | — | — |
| 6MF0 | Crystal Structure Determination of Human/Porcine Chimera Coagulation Factor VIII | x-ray diffraction | A, B | NAG, MAN, BMA, CA, ZN, CU1 | — |
| 6MF0 | Crystal structure determination of HUMAN/PORCINE chimera coagulation factor VIII | x-ray diffraction | A, B | NAG, MAN, BMA, CA, ZN, CU1 | — |
| 7K66 | Structure of Blood Coagulation Factor VIII in Complex with an Anti-C1 Domain Pathogenic Antibody… | x-ray diffraction | A | NAG, MAN, CU, CA, ZN | 15 (best 0.86) |
| 7K66 | Structure of blood coagulation factor VIII in complex with an anti-C1 domain pathogenic antibody… | x-ray diffraction | A | NAG, MAN, CU, CA, ZN | — |
| 7KBT | Factor VIII in complex with the anti-C2 domain antibody, G99 | x-ray diffraction | A | NAG, CU, ZN, CA | 18 (best 0.83) |
| 7KBT | Factor VIII in complex with the anti-C2 domain antibody, G99 | x-ray diffraction | A | NAG, CU, ZN, CA | — |
| 7S0P | Crystal structure of Porcine Factor VIII C2 Domain Bound to Phosphatidylserine | x-ray diffraction | M | SEP | — |
| 8G6I | Coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor | electron microscopy | A | NAG | 16 (best 0.89) |
| P12263 | AlphaFold monomer V2.0 prediction for coagulation factor VIII (P12263) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 7 records
- CA · Calcium ion · in 6 records
- ZN · Zinc ion · in 6 records
- CU · Copper (II) ion · in 4 records
- MAN · alpha-D-mannopyranose · in 4 records
- BMA · beta-D-mannopyranose · in 2 records
- CU1 · Copper (I) ion · in 2 records
- SEP · Phosphoserine · in 1 record
Experiment against prediction
- 6MF0 chain A against the predicted model P12263: TM-score 0.99, RMSD 1.21 Å
- 6MF0 chain A against the predicted model P12263: TM-score 0.99, RMSD 1.21 Å
- 4MO3 chain M against the predicted model P12263: TM-score 0.99, RMSD 0.54 Å
- 4MO3 chain M against the predicted model P12263: TM-score 0.99, RMSD 0.54 Å
- 6MF0 chain A against the predicted model P00451: TM-score 0.99, RMSD 1.28 Å
- 6MF0 chain A against the predicted model P00451: TM-score 0.99, RMSD 1.28 Å
- 7KBT chain A against the predicted model P12263: TM-score 0.98, RMSD 1.45 Å
- 7KBT chain A against the predicted model P12263: TM-score 0.98, RMSD 1.45 Å
- 7KBT chain A against the predicted model P00451: TM-score 0.98, RMSD 1.56 Å
- 7KBT chain A against the predicted model P00451: TM-score 0.98, RMSD 1.56 Å
Elsewhere
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