MolNFT v1 · #154966 · protein

Tric at 0.1 mm ADP-alfx, conformation 4, 0.1-C4

6KS8 · T-complex protein 1 subunit alpha: “Tric at 0.1 mm ADP-alfx, conformation 4, 0.1-C4”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #154966 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6KS8
Type: protein
Length: 8,120 residues
Chains: 16
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: T-complex protein 1 subunit alpha; T-complex protein 1 subunit beta; T-complex protein 1…
UniProt: P12612, P39076, P39078, P40413, P39077, P42943, P47079, P39079
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 15 distinct chains · 48% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
a	T-complex protein 1 subunit alpha	protein	519	45% helix, 13% strand	P12612
A	T-complex protein 1 subunit alpha	protein	512	44% helix, 12% strand	P12612
b	T-complex protein 1 subunit beta	protein	502	49% helix, 14% strand	P39076
B	T-complex protein 1 subunit beta	protein	489	50% helix, 14% strand	P39076
d	T-complex protein 1 subunit delta	protein	499	49% helix, 14% strand	P39078
D	T-complex protein 1 subunit delta	protein	480	49% helix, 14% strand	P39078
e	T-complex protein 1 subunit epsilon	protein	518	50% helix, 10% strand	P40413
E	T-complex protein 1 subunit epsilon	protein	502	47% helix, 11% strand	P40413
g	Fusion protein of T-complex protein 1 subunit gamma, rep- his-cbp and T-complex protein 1 subunit gamma	protein	493	49% helix, 10% strand	P39077
G	Fusion protein of T-complex protein 1 subunit gamma, rep- his-cbp and T-complex protein 1 subunit gamma	protein	485	49% helix, 10% strand	P39077
h, H	T-complex protein 1 subunit eta	protein	507	50% helix, 13% strand	P42943
q	T-complex protein 1 subunit theta	protein	523	46% helix, 13% strand	P47079
Q	T-complex protein 1 subunit theta	protein	524	45% helix, 13% strand	P47079
z	T-complex protein 1 subunit zeta	protein	531	51% helix, 11% strand	P39079
Z	T-complex protein 1 subunit zeta	protein	529	52% helix, 12% strand	P39079

Pockets

20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	985	0.85	0.86	117	empty
2	899	0.85	0.87	102	empty
3	1180	0.85	0.86	79	empty
4	494	0.85	0.91	50	empty
5	764	0.84	0.87	86	empty

Interfaces

35 interfaces between chains.

E–H · 2144 Å² buried · 14 hydrogen bonds · protein-protein
e–h · 2118 Å² buried · 12 hydrogen bonds · protein-protein
b–e · 1798 Å² buried · 20 hydrogen bonds · protein-protein
q–z · 1725 Å² buried · 12 hydrogen bonds · protein-protein
Q–Z · 1674 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

6KS8 · TRiC at 0.1 mM ADP-AlFx, Conformation 4, 0.1-C4 · the same entry in another collection · chain h against h, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P12612
Every structure of UniProt P39076
Every structure of UniProt P39078
Every structure of UniProt P40413
Every structure of UniProt P39077
Every structure of UniProt P42943
Every structure of UniProt P47079
Every structure of UniProt P39079
Elsewhere: RCSB PDB 6KS8 · PDBe 6KS8 · UniProt P12612 · UniProt P39076 · UniProt P39078 · UniProt P40413 · UniProt P39077 · UniProt P42943 · UniProt P47079 · UniProt P39079

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