UniProt P39078

T-complex protein 1 subunit delta (P39078)

T-complex protein 1 subunit delta (UniProt P39078): 21 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 104 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P39078
Protein: T-complex protein 1 subunit delta
Experimental structures: 21
Predicted models: 1
Ligands: 5
Pockets: 104 · 17 records with a druggable one

Structures

22 records of P39078 in the MolNFT archive: 21 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4V81	The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins	x-ray diffraction	D, L, d, l	ADP, BEF, SO4	9 (best 0.85)
4V8R	The crystal structures of the eukaryotic chaperonin CCT reveal its functional partitioning	x-ray diffraction	AD, Ad, BD, Bd	ADP, BEF, MG	7 (best 0.86)
4V94	Molecular architecture of the eukaryotic chaperonin TRiC/CCT derived by a combination of chemical…	x-ray diffraction	D, L, d, l	MG, ADP, BEF	7 (best 0.86)
5GW4	Structure of yeast npp-tric	electron microscopy	d, D	—	7 (best 0.85)
5GW5	Structure of TRiC-AMP-PNP	electron microscopy	d, D	—	8 (best 0.85)
5GW5	Structure of tric-AMP-pnp	electron microscopy	d, D	—	8 (best 0.85)
6KRD	TRiC at 0.05 mM ADP-AlFx, Conformation 4, 0.05-C4	electron microscopy	d, D	—	4 (best 0.86)
6KRD	Tric at 0.05 mm ADP-alfx, conformation 4, 0.05-C4	electron microscopy	d, D	—	—
6KRE	TRiC at 0.05 mM ADP-AlFx, Conformation 2, 0.05-C2	electron microscopy	d, D	—	3 (best 0.82)
6KRE	Tric at 0.05 mm ADP-alfx, conformation 2, 0.05-C2	electron microscopy	d, D	—	—
6KS6	TRiC at 0.2 mM ADP-AlFx, Conformation 1, 0.2-C1	electron microscopy	d, D	ADP, MG, AF3	6 (best 0.89)
6KS6	Tric at 0.2 mm ADP-alfx, conformation 1, 0.2-C1	electron microscopy	d, D	ADP, MG, AF3	—
6KS7	TRiC at 0.1 mM ADP-AlFx, Conformation 1, 0.1-C1	electron microscopy	d, D	—	3 (best 0.84)
6KS7	Tric at 0.1 mm ADP-alfx, conformation 1, 0.1-C1	electron microscopy	d, D	—	—
6KS8	TRiC at 0.1 mM ADP-AlFx, Conformation 4, 0.1-C4	electron microscopy	d, D	—	4 (best 0.83)
6KS8	Tric at 0.1 mm ADP-alfx, conformation 4, 0.1-C4	electron microscopy	d, D	—	—
7YLU	yeast TRiC-plp2-substrate complex at S1 TRiC-NPP state	electron microscopy	D, d	—	8 (best 0.84)
7YLV	yeast TRiC-plp2-substrate complex at S2 ATP binding state	electron microscopy	D, d	—	7 (best 0.85)
7YLW	yeast TRiC-plp2-tubulin complex at S3 closed TRiC state	electron microscopy	D, d	ADP, MG, AF3	7 (best 0.89)
7YLX	yeast TRiC-plp2-actin complex at S4 closed TRiC state	electron microscopy	D, d	ADP, MG, AF3	6 (best 0.90)
7YLY	yeast TRiC-plp2 complex at S5 closed TRiC state	electron microscopy	D, d	ADP, MG, AF3	7 (best 0.90)
P39078	AlphaFold monomer V2.0 prediction for T-complex protein 1 subunit delta (P39078)	predicted	A	—	3 (best 0.77)

Ligands

ADP · Adenosine-5'-diphosphate · in 8 records
MG · Magnesium ion · in 7 records
AF3 · Aluminum fluoride · in 5 records
BEF · Beryllium trifluoride ion · in 3 records
SO4 · Sulfate ion · in 1 record

Experiment against prediction

4V8R chain AD against the predicted model P39078: TM-score 0.93, RMSD 2.34 Å
4V94 chain D against the predicted model P39078: TM-score 0.93, RMSD 2.30 Å
6KS6 chain D against the predicted model P39078: TM-score 0.92, RMSD 2.34 Å
6KS6 chain D against the predicted model P39078: TM-score 0.92, RMSD 2.34 Å
7YLW chain D against the predicted model P39078: TM-score 0.92, RMSD 2.39 Å
7YLY chain D against the predicted model P39078: TM-score 0.92, RMSD 2.42 Å
7YLX chain D against the predicted model P39078: TM-score 0.92, RMSD 2.42 Å
6KS6 chain d against the predicted model P39078: TM-score 0.92, RMSD 2.38 Å
6KS6 chain d against the predicted model P39078: TM-score 0.92, RMSD 2.38 Å
7YLX chain d against the predicted model P39078: TM-score 0.92, RMSD 2.43 Å

Elsewhere

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