UniProt P39077

T-complex protein 1 subunit gamma (P39077)

T-complex protein 1 subunit gamma (UniProt P39077): 21 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 98 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.

UniProt: P39077
Protein: T-complex protein 1 subunit gamma
Experimental structures: 21
Predicted models: 1
Ligands: 5
Pockets: 98 · 22 records with a druggable one

Structures

22 records of P39077 in the MolNFT archive: 21 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
4V81	The crystal structure of yeast CCT reveals intrinsic asymmetry of eukaryotic cytosolic chaperonins	x-ray diffraction	C, K, c, k	ADP, BEF, SO4	5 (best 0.87)
4V8R	The crystal structures of the eukaryotic chaperonin CCT reveal its functional partitioning	x-ray diffraction	AG, Ag, BG, Bg	ADP, BEF, MG	4 (best 0.85)
4V94	Molecular architecture of the eukaryotic chaperonin TRiC/CCT derived by a combination of chemical…	x-ray diffraction	C, K, c, k	MG, ADP, BEF	6 (best 0.82)
5GW4	Structure of yeast npp-tric	electron microscopy	g, G	—	6 (best 0.83)
5GW5	Structure of TRiC-AMP-PNP	electron microscopy	g, G	—	3 (best 0.86)
5GW5	Structure of tric-AMP-pnp	electron microscopy	g, G	—	3 (best 0.86)
6KRD	TRiC at 0.05 mM ADP-AlFx, Conformation 4, 0.05-C4	electron microscopy	g, G	—	2 (best 0.87)
6KRD	Tric at 0.05 mm ADP-alfx, conformation 4, 0.05-C4	electron microscopy	g, G	—	2 (best 0.87)
6KRE	TRiC at 0.05 mM ADP-AlFx, Conformation 2, 0.05-C2	electron microscopy	g, G	—	5 (best 0.86)
6KRE	Tric at 0.05 mm ADP-alfx, conformation 2, 0.05-C2	electron microscopy	g, G	—	5 (best 0.86)
6KS6	TRiC at 0.2 mM ADP-AlFx, Conformation 1, 0.2-C1	electron microscopy	g, G	ADP, MG, AF3	6 (best 0.88)
6KS6	Tric at 0.2 mm ADP-alfx, conformation 1, 0.2-C1	electron microscopy	g, G	ADP, MG, AF3	6 (best 0.88)
6KS7	TRiC at 0.1 mM ADP-AlFx, Conformation 1, 0.1-C1	electron microscopy	g, G	—	3 (best 0.87)
6KS7	Tric at 0.1 mm ADP-alfx, conformation 1, 0.1-C1	electron microscopy	g, G	—	3 (best 0.87)
6KS8	TRiC at 0.1 mM ADP-AlFx, Conformation 4, 0.1-C4	electron microscopy	g, G	—	3 (best 0.85)
6KS8	Tric at 0.1 mm ADP-alfx, conformation 4, 0.1-C4	electron microscopy	g, G	—	3 (best 0.85)
7YLU	yeast TRiC-plp2-substrate complex at S1 TRiC-NPP state	electron microscopy	G, g	—	4 (best 0.83)
7YLV	yeast TRiC-plp2-substrate complex at S2 ATP binding state	electron microscopy	G, g	—	4 (best 0.85)
7YLW	yeast TRiC-plp2-tubulin complex at S3 closed TRiC state	electron microscopy	G, g	ADP, MG, AF3	7 (best 0.88)
7YLX	yeast TRiC-plp2-actin complex at S4 closed TRiC state	electron microscopy	G, g	ADP, MG, AF3	8 (best 0.90)
7YLY	yeast TRiC-plp2 complex at S5 closed TRiC state	electron microscopy	G, g	ADP, MG, AF3	8 (best 0.90)
P39077	AlphaFold monomer V2.0 prediction for T-complex protein 1 subunit gamma (P39077)	predicted	A	—	2 (best 0.79)

Ligands

ADP · Adenosine-5'-diphosphate · in 8 records
MG · Magnesium ion · in 7 records
AF3 · Aluminum fluoride · in 5 records
BEF · Beryllium trifluoride ion · in 3 records
SO4 · Sulfate ion · in 1 record

Experiment against prediction

4V8R chain AG against the predicted model P39077: TM-score 0.99, RMSD 0.93 Å
4V94 chain C against the predicted model P39077: TM-score 0.98, RMSD 1.16 Å
6KS6 chain g against the predicted model P39077: TM-score 0.97, RMSD 1.50 Å
6KS6 chain g against the predicted model P39077: TM-score 0.97, RMSD 1.50 Å
7YLW chain g against the predicted model P39077: TM-score 0.97, RMSD 1.68 Å
7YLX chain g against the predicted model P39077: TM-score 0.97, RMSD 1.69 Å
7YLY chain g against the predicted model P39077: TM-score 0.97, RMSD 1.69 Å
6KS6 chain G against the predicted model P39077: TM-score 0.97, RMSD 1.45 Å
6KS6 chain G against the predicted model P39077: TM-score 0.97, RMSD 1.45 Å
7YLW chain G against the predicted model P39077: TM-score 0.97, RMSD 1.49 Å

Elsewhere

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