MolNFT v1 · #15355 · protein
Crystal structure of the H48Q mutant of human group iia phospholipase A2
1N28 · Phospholipase A2, membrane associated: “Crystal structure of the H48Q mutant of human group iia phospholipase A2”. X-ray diffraction, 1 ligand (CA), 2 pockets (best druggability 0.51). MolNFT v1 #15355 on GenesisL1: 3D structure…
- PDB
- 1N28
- Type
- protein
- Length
- 248 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phospholipase A2, membrane associated
- EC
- 3.1.1.4
- UniProt
- P14555
- Ligands
- CA
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | Phospholipase A2, membrane associated (EC 3.1.1.4) | protein | 124 | 51% helix, 6% strand | P14555 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 124 | 0.51 | 0.80 | 22 | empty |
| 2 | 111 | 0.49 | 0.80 | 20 | empty |
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
- 1N28 · Crystal structure of the H48Q mutant of human group IIA phospholipase A2 · the same entry in another collection · chain B against B, TM-score 1.00
- P14555 · AlphaFold monomer V2.0 prediction for phospholipase A2, membrane associated (P14555) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14555
- Elsewhere: RCSB PDB 1N28 · PDBe 1N28 · UniProt P14555
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