Research workbench
Crystal structure of the H48Q mutant of human group iia phospholipase A2
Analyse Crystal structure of the H48Q mutant of human group iia phospholipase A2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1N28
- Type
- protein
- Length
- 248 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phospholipase A2, membrane associated
- EC
- 3.1.1.4
- UniProt
- P14555
- Ligands
- CA
- Pockets
- 2 · best druggability 0.51
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B, A | Phospholipase A2, membrane associated (EC 3.1.1.4) | protein | 124 | 51% helix, 6% strand | P14555 |
Ligands and binding sites
- CA · Calcium ion · metal · 4 copies · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 124 | 0.51 | 0.80 | 22 | empty |
| 2 | 111 | 0.49 | 0.80 | 20 | empty |
Modifications
Observed in the structure: 14 disulfide (disulfide).
Compared structures
- 1N28 · Crystal structure of the H48Q mutant of human group IIA phospholipase A2 · the same entry in another collection · chain B against B, TM-score 1.00
- P14555 · AlphaFold monomer V2.0 prediction for phospholipase A2, membrane associated (P14555) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14555
- Elsewhere: RCSB PDB 1N28 · PDBe 1N28 · UniProt P14555
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