UniProt P14555
Phospholipase A2, membrane associated (P14555)
Phospholipase A2, membrane associated (UniProt P14555): 34 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P14555
- Protein
- Phospholipase A2, membrane associated
- Experimental structures
- 34
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 1 · 1 record with a druggable one
Structures
35 records of P14555 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1AYP | A probe molecule composed of seventeen percent of total diffracting matter gives correct solutions… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1AYP | A probe molecule composed of seventeen percent of total diffracting matter gives correct solutions… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1BBC | Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2… | x-ray diffraction | A | — | — |
| 1BBC | Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2… | x-ray diffraction | A | — | — |
| 1DB4 | Human S-PLA2 in complex with indole 8 | x-ray diffraction | A | — | — |
| 1DB4 | Human S-PLA2 in complex with indole 8 | x-ray diffraction | A | — | — |
| 1DB5 | Human S-PLA2 in complex with indole 6 | x-ray diffraction | A | — | — |
| 1DB5 | Human S-PLA2 in complex with indole 6 | x-ray diffraction | A | — | — |
| 1DCY | Crystal structure of human S-PLA2 in complex with indole 3 active site inhibitor | x-ray diffraction | A | — | — |
| 1DCY | Crystal structure of human S-PLA2 in complex with indole 3 active site inhibitor | x-ray diffraction | A | — | — |
| 1J1A | PANCREATIC SECRETORY PHOSPHOLIPASE A2 (IIa) WITH ANTI-INFLAMMATORY ACTIVITY | x-ray diffraction | A, B | — | — |
| 1J1A | Pancreatic secretory phospholipase A2 (iia) with anti- inflammatory activity | x-ray diffraction | A, B | — | — |
| 1KQU | Human phospholipase A2 complexed with a substrate anologue | x-ray diffraction | A | — | — |
| 1KQU | Human phospholipase A2 complexed with a substrate anologue | x-ray diffraction | A | — | — |
| 1KVO | Human phospholipase A2 complexed with a highly potent substrate anologue | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1KVO | Human phospholipase A2 complexed with a highly potent substrate anologue | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1N28 | Crystal structure of the H48Q mutant of human group IIA phospholipase A2 | x-ray diffraction | B, A | — | — |
| 1N28 | Crystal structure of the H48Q mutant of human group iia phospholipase A2 | x-ray diffraction | B, A | — | — |
| 1N29 | Crystal structure of the N1A mutant of human group IIA phospholipase A2 | x-ray diffraction | A | — | — |
| 1N29 | Crystal structure of the N1A mutant of human group iia phospholipase A2 | x-ray diffraction | A | — | — |
| 1POD | Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate | x-ray diffraction | A | — | — |
| 1POD | Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate | x-ray diffraction | A | — | — |
| 1POE | Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate | x-ray diffraction | A, B | — | — |
| 1POE | Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate | x-ray diffraction | A, B | — | — |
| 3U8B | Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in… | x-ray diffraction | A | — | — |
| 3U8B | Functionally selective inhibition of group iia phospholipase A2 reveals a role for vimentin in… | x-ray diffraction | A | — | — |
| 3U8D | Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in… | x-ray diffraction | A, B | — | — |
| 3U8D | Functionally selective inhibition of group iia phospholipase A2 reveals a role for vimentin in… | x-ray diffraction | A, B | — | — |
| 3U8H | Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in… | x-ray diffraction | A, B | — | — |
| 3U8H | Functionally selective inhibition of group iia phospholipase A2 reveals a role for vimentin in… | x-ray diffraction | A, B | — | — |
| 3U8I | Functionally selective inhibition of Group IIA phospholipase A2 reveals a role for vimentin in… | x-ray diffraction | A, B | — | — |
| 3U8I | Functionally selective inhibition of group iia phospholipase A2 reveals a role for vimentin in… | x-ray diffraction | A, B | — | — |
| 5G3N | Discovery of a novel secreted phospholipase A2 (sPLA2) inhibitor. | x-ray diffraction | A, B | CA, X28 | — |
| 5G3N | Discovery of a novel secreted phospholipase A2 (SPLA2) inhibitor. | x-ray diffraction | A, B | — | — |
| P14555 | AlphaFold monomer V2.0 prediction for phospholipase A2, membrane associated (P14555) | predicted | A | — | 1 (best 0.56) |
Ligands
Experiment against prediction
- 1KVO chain A against the predicted model P14555: TM-score 0.98, RMSD 0.52 Å
- 1KVO chain A against the predicted model P14555: TM-score 0.98, RMSD 0.52 Å
- 1KQU chain A against the predicted model P14555: TM-score 0.98, RMSD 0.54 Å
- 1KQU chain A against the predicted model P14555: TM-score 0.98, RMSD 0.54 Å
- 3U8H chain A against the predicted model P14555: TM-score 0.98, RMSD 0.54 Å
- 3U8H chain A against the predicted model P14555: TM-score 0.98, RMSD 0.54 Å
- 1J1A chain A against the predicted model P14555: TM-score 0.98, RMSD 0.55 Å
- 1J1A chain A against the predicted model P14555: TM-score 0.98, RMSD 0.55 Å
- 1DCY chain A against the predicted model P14555: TM-score 0.98, RMSD 0.58 Å
- 1DCY chain A against the predicted model P14555: TM-score 0.98, RMSD 0.58 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.