MolNFT v1 · #152337 · protein

The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine

6IEJ: “The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine”. X-ray diffraction, 3 ligands (HXG, CA, MG). MolNFT v1 #152337 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6IEJ
Type: protein
Length: 378 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytosolic phospholipase A2
EC: 3.1.1.4
UniProt: P49147
Ligands: HXG, CA, MG

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Cytosolic phospholipase A2 (EC 3.1.1.4)	protein	126	7% helix, 53% strand	P49147

Ligands and binding sites

HXG · 1,2-dihexanoyl-sn-glycero-3-phosphocholine · ligand · 3 copies · chains A, B, C
CA · Calcium ion · metal · 9 copies · chains A, B, C
MG · Magnesium ion · metal · 2 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

2 interfaces between chains.

A–B · 286 Å² buried · 8 hydrogen bonds · protein-protein
B–C · 102 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

6IEJ · The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine · the same entry in another collection · chain A against A, TM-score 1.00
P49147 · AlphaFold monomer V2.0 prediction for cytosolic phospholipase A2 (P49147) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P49147
Elsewhere: RCSB PDB 6IEJ · PDBe 6IEJ · UniProt P49147

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