The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 53% strand (DSSP).

Ligands and binding sites

• HXG · 1,2-dihexanoyl-sn-glycero-3-phosphocholine · ligand · 3 copies · chains A, B, C
• CA · Calcium ion · metal · 9 copies · chains A, B, C
• MG · Magnesium ion · metal · 2 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

2 interfaces between chains.

• A–B · 286 Ų buried · 8 hydrogen bonds · protein-protein
• B–C · 102 Ų buried · 0 hydrogen bonds · protein-protein

Compared structures

• 6IEJ · The C2 domain of cytosolic phospholipase A2 alpha bound to phosphatidylcholine · the same entry in another collection · chain A against A, TM-score 1.00
• P49147 · AlphaFold monomer V2.0 prediction for cytosolic phospholipase A2 (P49147) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P49147
• Elsewhere: RCSB PDB 6IEJ · PDBe 6IEJ · UniProt P49147