Yeast 20S proteasome with human BETA2I (1-53) in complex with onx 0914

Structure

x-ray diffraction · 15 distinct chains.

Ligands and binding sites

• GQK · (2~{S})-3-(4-methoxyphenyl)-~{N}-[(2~{S},3~{R})-4-methyl-3,4-bis(oxidanyl)-1-phenyl-pentan-2-yl]-2-[[(2~{S})-2-(2-morpholin-4-ylethanoylamino) propanoyl]amino]propanamide · ligand · 6 copies · chains H, I, K, L, N, V, W, Y, Z, b
• MG · Magnesium ion · metal · 8 copies · chains G, I, K, W, N, a, L, V, Y, H, Z
• CL · Chloride ion · ion · 2 copies · chains G, H, U, V
• SO4 · Sulfate ion · ion · 2 copies · chains N, b
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · 4 copies · chains H, Z, J, K, L, V, X, Y

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6HV4 · Yeast 20S proteasome with human beta2i (1-53) in complex with ONX 0914 · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P23639
• Every structure of UniProt P23638
• Every structure of UniProt P40303
• Every structure of UniProt P32379
• Every structure of UniProt P40302
• Every structure of UniProt P21242
• Every structure of UniProt P21243
• Every structure of UniProt P40306
• Every structure of UniProt P25043
• Every structure of UniProt P25451
• Every structure of UniProt P22141
• Every structure of UniProt P30656
• Every structure of UniProt P23724
• Every structure of UniProt P30657
• Every structure of UniProt P38624
• Elsewhere: RCSB PDB 6HV4 · PDBe 6HV4 · UniProt P23639 · UniProt P23638 · UniProt P40303 · UniProt P32379 · UniProt P40302 · UniProt P21242 · UniProt P21243 · UniProt P40306 · UniProt P25043 · UniProt P25451 · UniProt P22141 · UniProt P30656 · UniProt P23724 · UniProt P30657 · UniProt P38624