X-ray structure of human glutamate carboxypeptidase II (gcpii) in complex with a inhibitor RNA 1-79-1

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 19% strand (DSSP).

Ligands and binding sites

• TAM · Tris(hydroxyethyl)aminomethane · ligand · 2 copies · chains A
• FVZ · (2~{S})-2-[[(2~{S})-6-[(4-fluorophenyl)amino]-1-oxidanyl-1,6-bis(oxidanylidene)hexan-2-yl]carbamoylamino]pentanedioic acid · ligand · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 11 copies · chains A
• MAN · alpha-D-mannopyranose · sugar · 3 copies · chains A
• BMA · beta-D-mannopyranose · sugar · 2 copies · chains A
• ZN · Zinc ion · metal · 2 copies · chains A
• CA · Calcium ion · metal · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• EDO · 1,2-ethanediol · additive · 6 copies · chains A
• PEG · Di(hydroxyethyl)ether · additive · 3 copies · chains A
• PGE · Triethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Modifications

Observed in the structure: 7 glycan (N-glycosylation).

Compared structures

• 6H7Y · X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a… · the same entry in another collection · chain A against A, TM-score 1.00
• Q04609 · AlphaFold monomer V2.0 prediction for glutamate carboxypeptidase 2 (Q04609) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q04609
• Elsewhere: RCSB PDB 6H7Y · PDBe 6H7Y · UniProt Q04609