Cryo-EM structure of the adenosine A2A receptor bound to a minigs heterotrimer

Structure

electron microscopy · 5 distinct chains.

Ligands and binding sites

• NEC · N-ethyl-5'-carboxamido adenosine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6GDG · Cryo-EM structure of the adenosine A2A receptor bound to a miniGs heterotrimer · the same entry in another collection · chain E against E, TM-score 1.00
• P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
• P29274 · AlphaFold monomer V2.0 prediction for adenosine receptor A2A (P29274) · a predicted model of the same protein · chain A against A, TM-score 0.91
• P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.87
• P63092 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain D against A, TM-score 0.86

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q14F07
• Every structure of UniProt P29274
• Every structure of UniProt P62873
• Every structure of UniProt P59768
• Every structure of UniProt P63092
• Elsewhere: RCSB PDB 6GDG · PDBe 6GDG · UniProt Q14F07 · UniProt P29274 · UniProt P62873 · UniProt P59768 · UniProt P63092