MolNFT v1 · #147332 · protein
Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD0059 bound
6E9P: “Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD0059 bound”. X-ray diffraction, 2 ligands (HDJ, MLT). MolNFT v1 #147332 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6E9P
- Type
- protein
- Length
- 2,602 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P9WFY1, P9WFX9
- Ligands
- HDJ, MLT
Structure
x-ray diffraction · 7 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 249 | — | P9WFY1 |
| B, D | — | protein | 405 | — | P9WFX9 |
| C | — | protein | 249 | — | P9WFY1 |
| E | — | protein | 246 | — | P9WFY1 |
| F | — | protein | 399 | — | P9WFX9 |
| G | — | protein | 249 | — | P9WFY1 |
| H | — | protein | 400 | — | P9WFX9 |
Ligands and binding sites
- HDJ · (2R,3S,4R)-3-(2',6'-difluoro-4'-methyl[1,1'-biphenyl]-4-yl)-4-(fluoromethyl)azetidine-2-carbonitrile · ligand · 4 copies · chains A, B, C, D, E, F, G, H
- MLT · D-malate · ligand · chains B, F
- FMT · Formic acid · additive · 29 copies · chains B, H, A, C, D, F
- EDO · 1,2-ethanediol · additive · 13 copies · chains A, B, D, E, F, H, G
- ACT · Acetate ion · additive · 5 copies · chains A, B, G, H
- MLA · Malonic acid · additive · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6E9P · Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD0059… · the same entry in another collection · chain H against H, TM-score 1.00
- P9WFY1 · AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (P9WFY1) · a predicted model of the same protein · chain A against A, TM-score 1.00
- P9WFX9 · AlphaFold monomer V2.0 prediction for tryptophan synthase beta chain (P9WFX9) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P9WFY1
- Every structure of UniProt P9WFX9
- Elsewhere: RCSB PDB 6E9P · PDBe 6E9P · UniProt P9WFY1 · UniProt P9WFX9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.