MolNFT v1 · #146045 · protein

RAS:SOS:RAS in complex with a small molecule activator

6D5V: “RAS:SOS:RAS in complex with a small molecule activator”. X-ray diffraction, 3 ligands (GNP, FVY, MG). MolNFT v1 #146045 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6D5V
Type: protein
Length: 800 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P01112, Q07889
Ligands: GNP, FVY, MG

Structure

x-ray diffraction · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
Q	—	protein	166	—	P01112
R	—	protein	167	—	P01112
S	—	protein	467	—	Q07889

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains Q
FVY · 1-[(3-chloro-4-fluorophenyl)methyl]-5,6-dimethyl-1H-benzimidazol-2-amine · ligand · chains S
MG · Magnesium ion · metal · chains Q

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6D5V · Ras:SOS:Ras in complex with a small molecule activator · the same entry in another collection · chain Q against Q, TM-score 1.00
Q07889 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889) · a predicted model of the same protein · chain S against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P01112
Every structure of UniProt Q07889
Elsewhere: RCSB PDB 6D5V · PDBe 6D5V · UniProt P01112 · UniProt Q07889

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