MolNFT v1 · #145424 · protein
Cryo-EM structure of the human SK4/CALMODULIN channel complex in the CA2+ bound state II
6CNO · Intermediate conductance calcium-activated potassium…: “Cryo-EM structure of the human SK4/CALMODULIN channel complex in the CA2+ bound state II”. Electron microscopy, 1 ligand (CA), 20 pockets (best druggability 0.84). MolNFT v1…
- PDB
- 6CNO
- Type
- protein
- Length
- 2,024 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Intermediate conductance calcium-activated potassium channel protein 4; Calmodulin-1
- UniProt
- O15554, P0DP23
- Ligands
- CA
- Pockets
- 20 · best druggability 0.84
Structure
electron microscopy · 2 distinct chains · 73% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Intermediate conductance calcium-activated potassium channel protein 4 | protein | 360 | 80% helix, 0% strand | O15554 |
| E, F, G, H | Calmodulin-1 | protein | 146 | 58% helix, 3% strand | P0DP23 |
Ligands and binding sites
- CA · Calcium ion · metal · 12 copies · chains E, F, G, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1029 | 0.84 | 0.85 | 119 | empty |
| 2 | 1016 | 0.83 | 0.84 | 108 | empty |
| 3 | 1017 | 0.82 | 0.83 | 99 | empty |
| 4 | 1048 | 0.82 | 0.83 | 111 | empty |
| 5 | 514 | 0.78 | 0.85 | 36 | empty |
Interfaces
18 interfaces between chains.
- A–B · 1467 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 1467 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 1465 Ų buried · 7 hydrogen bonds · protein-protein
- A–D · 1458 Ų buried · 7 hydrogen bonds · protein-protein
- A–G · 1039 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6CNO · Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state II · the same entry in another collection · chain H against H, TM-score 1.00
- O15554 · AlphaFold monomer V2.0 prediction for intermediate conductance calcium-activated… · a predicted model of the same protein · chain A against A, TM-score 0.85
- P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain G against A, TM-score 0.48
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15554
- Every structure of UniProt P0DP23
- Elsewhere: RCSB PDB 6CNO · PDBe 6CNO · UniProt O15554 · UniProt P0DP23
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