MolNFT v1 · #144639 · protein

Human ABCC6 NBD2 in ADP-bound state

6BZR · Multidrug resistance-associated protein 6: “Human ABCC6 NBD2 in ADP-bound state”. X-ray diffraction, 1 ligand (ADP), 5 pockets (best druggability 0.69). MolNFT v1 #144639 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6BZR
Type: protein
Length: 473 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Multidrug resistance-associated protein 6
UniProt: O95255
Ligands: ADP
Pockets: 5 · best druggability 0.69

Structure

x-ray diffraction · 2 distinct chains · 37% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Multidrug resistance-associated protein 6	protein	237	36% helix, 24% strand	O95255
A	Multidrug resistance-associated protein 6	protein	236	37% helix, 25% strand	O95255

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains B, A
CIT · Citric acid · additive · 2 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	374	0.69	0.82	49	empty
2	449	0.68	0.79	65	empty
3	152	0.47	0.77	26	empty
4	157	0.45	0.75	26	empty
5	83	0.41	0.78	14	empty

Interfaces

1 interface between chains.

B–A · 596 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

6BZR · Human ABCC6 NBD2 in ADP-bound state · the same entry in another collection · chain B against B, TM-score 1.00
O95255 · AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 6 (O95255) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95255
Elsewhere: RCSB PDB 6BZR · PDBe 6BZR · UniProt O95255

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