UniProt O95255
Multidrug resistance-associated protein 6 (O95255)
Multidrug resistance-associated protein 6 (UniProt O95255): 8 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 27 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O95255
- Protein
- Multidrug resistance-associated protein 6
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 27 · 3 records with a druggable one
Structures
9 records of O95255 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6BZR | Human ABCC6 NBD2 in ADP-bound state | x-ray diffraction | B, A | ADP | 5 (best 0.69) |
| 6BZR | Human ABCC6 NBD2 in ADP-bound state | x-ray diffraction | B, A | ADP | — |
| 6BZS | Human ABCC6 NBD1 in Apo state | x-ray diffraction | A | SO4 | 2 (best 0.50) |
| 6BZS | Human ABCC6 NBD1 in apo state | x-ray diffraction | A | SO4 | — |
| 6NLO | Human ABCC6 NBD1 H812A in Apo state | x-ray diffraction | A | SO4 | — |
| 6NLO | Human ABCC6 NBD1 H812A in apo state | x-ray diffraction | A | SO4 | — |
| 6P7F | Human ABCC6 NBD2 R1459D mutant in Apo state | x-ray diffraction | A | SO4 | — |
| 6P7F | Human ABCC6 NBD2 R1459D mutant in apo state | x-ray diffraction | A | SO4 | — |
| O95255 | AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 6 (O95255) | predicted | A | — | 20 (best 0.86) |
Ligands
Experiment against prediction
- 6NLO chain A against the predicted model O95255: TM-score 0.97, RMSD 1.19 Å
- 6NLO chain A against the predicted model O95255: TM-score 0.97, RMSD 1.19 Å
- 6BZS chain A against the predicted model O95255: TM-score 0.97, RMSD 1.43 Å
- 6BZS chain A against the predicted model O95255: TM-score 0.97, RMSD 1.43 Å
- 6BZR chain A against the predicted model O95255: TM-score 0.96, RMSD 1.26 Å
- 6BZR chain A against the predicted model O95255: TM-score 0.96, RMSD 1.26 Å
- 6BZR chain B against the predicted model O95255: TM-score 0.95, RMSD 1.38 Å
- 6BZR chain B against the predicted model O95255: TM-score 0.95, RMSD 1.38 Å
- 6P7F chain A against the predicted model O95255: TM-score 0.94, RMSD 1.56 Å
- 6P7F chain A against the predicted model O95255: TM-score 0.94, RMSD 1.56 Å
Elsewhere
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