MolNFT v1 · #244203 · protein
AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 6 (O95255)
O95255: “AlphaFold monomer V2.0 prediction for ATP-binding cassette sub-family C member 6 (O95255)”. 20 pockets (best druggability 0.86). MolNFT v1 #244203 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O95255
- Type
- protein
- Length
- 1,503 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9CEd9D970D1D6A73F17D1B47f0bAAF860B666B0D
- Molecule
- ATP-binding cassette sub-family C member 6
- UniProt
- O95255
- Pockets
- 20 · best druggability 0.86
Structure
1 distinct chain · 62% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP-binding cassette sub-family C member 6 | protein | 1503 | 62% helix, 9% strand | O95255 |
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 992 | 0.86 | 0.87 | 91 | empty |
| 2 | 385 | 0.79 | 0.88 | 36 | empty |
| 3 | 1074 | 0.73 | 0.76 | 70 | empty |
| 4 | 176 | 0.66 | 0.86 | 30 | empty |
| 5 | 169 | 0.62 | 0.84 | 27 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 6P7F · Human ABCC6 NBD2 R1459D mutant in apo state · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 6P7F · Human ABCC6 NBD2 R1459D mutant in Apo state · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 6BZR · Human ABCC6 NBD2 in ADP-bound state · an experimental structure of the same protein · chain A against B, TM-score 0.16
- 6BZR · Human ABCC6 NBD2 in ADP-bound state · an experimental structure of the same protein · chain A against B, TM-score 0.16
- 6BZS · Human ABCC6 NBD1 in apo state · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 6BZS · Human ABCC6 NBD1 in Apo state · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 6NLO · Human ABCC6 NBD1 H812A in Apo state · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 6NLO · Human ABCC6 NBD1 H812A in apo state · an experimental structure of the same protein · chain A against A, TM-score 0.15
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95255
- Elsewhere: UniProt O95255 · AlphaFold DB O95255
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