MolNFT v1 · #140047 · protein

Crystal structure of the human TIN2-TPP1-TRF2 telomeric complex

5XYF · TERF1-interacting nuclear factor 2: “Crystal structure of the human TIN2-TPP1-TRF2 telomeric complex”. X-ray diffraction, 1 pocket (best druggability 0.43). MolNFT v1 #140047 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 5XYF
Type: protein
Length: 229 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TERF1-interacting nuclear factor 2; Telomeric repeat-binding factor 2; Adrenocortical…
UniProt: Q9BSI4, Q15554, Q96AP0
Pockets: 1 · best druggability 0.43

Structure

x-ray diffraction · 3 distinct chains · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TERF1-interacting nuclear factor 2	protein	192	71% helix, 0% strand	Q9BSI4
C	Telomeric repeat-binding factor 2	protein	12	50% helix, 0% strand	Q15554
B	Adrenocortical dysplasia protein homolog	protein	25	68% helix, 0% strand	Q96AP0

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	150	0.43	0.75	22	empty

Interfaces

2 interfaces between chains.

A–B · 1197 Å² buried · 4 hydrogen bonds · protein-protein
A–C · 738 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

5XYF · Crystal structure of the human TIN2-TPP1-TRF2 telomeric complex · the same entry in another collection · chain A against A, TM-score 1.00
Q9BSI4 · AlphaFold monomer V2.0 prediction for TERF1-interacting nuclear factor 2 (Q9BSI4) · a predicted model of the same protein · chain A against A, TM-score 0.99
Q15554 · AlphaFold monomer V2.0 prediction for telomeric repeat-binding factor 2 (Q15554) · a predicted model of the same protein · chain C against A, TM-score 0.60
Q96AP0 · AlphaFold monomer V2.0 prediction for adrenocortical dysplasia protein homolog (Q96AP0) · a predicted model of the same protein · chain B against A, TM-score 0.51

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9BSI4
Every structure of UniProt Q15554
Every structure of UniProt Q96AP0
Elsewhere: RCSB PDB 5XYF · PDBe 5XYF · UniProt Q9BSI4 · UniProt Q15554 · UniProt Q96AP0

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