MolNFT v1 · #138713 · protein
Complex structure of human SRP72/SRP68
5WRV · Signal recognition particle subunit SRP68: “Complex structure of human SRP72/SRP68”. X-ray diffraction, 2 ligands (NA, SO4), 1 pocket (best druggability 0.42). MolNFT v1 #138713 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5WRV
- Type
- protein
- Length
- 177 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Signal recognition particle subunit SRP68; Signal recognition particle subunit SRP72
- UniProt
- Q9UHB9, O76094
- Ligands
- NA, SO4
- Pockets
- 1 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 68% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Signal recognition particle subunit SRP68 | protein | 23 | 39% helix, 0% strand | Q9UHB9 |
| B | Signal recognition particle subunit SRP72 | protein | 154 | 72% helix, 0% strand | O76094 |
Ligands and binding sites
- NA · Sodium ion · metal · chains A, B
- SO4 · Sulfate ion · ion · 2 copies · chains B
- GOL · Glycerol · additive · 5 copies · chains A, B
- ACT · Acetate ion · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 113 | 0.42 | 0.76 | 20 | SO4 |
Interfaces
1 interface between chains.
- A–B · 1243 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 5WRV · Complex structure of human SRP72/SRP68 · the same entry in another collection · chain A against A, TM-score 1.00
- O76094 · AlphaFold monomer V2.0 prediction for signal recognition particle subunit SRP72 (O76094) · a predicted model of the same protein · chain B against A, TM-score 0.95
- Q9UHB9 · AlphaFold monomer V2.0 prediction for signal recognition particle subunit SRP68 (Q9UHB9) · a predicted model of the same protein · chain A against A, TM-score 0.61
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UHB9
- Every structure of UniProt O76094
- Elsewhere: RCSB PDB 5WRV · PDBe 5WRV · UniProt Q9UHB9 · UniProt O76094
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