UniProt O76094
Signal recognition particle subunit SRP72 (O76094)
Signal recognition particle subunit SRP72 (UniProt O76094): 11 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- O76094
- Protein
- Signal recognition particle subunit SRP72
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 26 · 4 records with a druggable one
Structures
12 records of O76094 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5M72 | Structure of the human SRP68-72 protein-binding domain complex | x-ray diffraction | A | SO4, K | — |
| 5M72 | Structure of the human SRP68-72 protein-binding domain complex | x-ray diffraction | A | SO4, K | — |
| 5M73 | Structure of the human SRP S domain with SRP72 RNA-binding domain | x-ray diffraction | D, H | MG, K | 7 (best 0.73) |
| 5M73 | Structure of the human srp S domain with SRP72 RNA-binding domain | x-ray diffraction | D, H | K | — |
| 5WRV | Complex structure of human SRP72/SRP68 | x-ray diffraction | B | SO4, NA | 1 (best 0.42) |
| 5WRV | Complex structure of human SRP72/SRP68 | x-ray diffraction | B | SO4, NA | — |
| 5WRW | Structure of human apo-SRP72 | x-ray diffraction | A, B, C, D, E, F | SO4 | 5 (best 0.49) |
| 5WRW | Structure of human apo-SRP72 | x-ray diffraction | A, B, C, D, E, F | SO4 | — |
| 7NFX | Mammalian ribosome nascent chain complex with SRP and SRP receptor in early state A | electron microscopy | z | — | — |
| 8QVW | Cryo-EM structure of the peptide binding domain of human SRP68/72 | electron microscopy | B | — | 4 (best 0.56) |
| 8QVX | Structure of the PBD of human SRP68/72 (cryoSPARC 3DFlex) | electron microscopy | B | — | 4 (best 0.63) |
| O76094 | AlphaFold monomer V2.0 prediction for signal recognition particle subunit SRP72 (O76094) | predicted | A | — | 5 (best 0.72) |
Ligands
Experiment against prediction
- 5WRW chain A against the predicted model O76094: TM-score 0.97, RMSD 0.95 Å
- 5WRW chain A against the predicted model O76094: TM-score 0.97, RMSD 0.95 Å
- 5WRV chain B against the predicted model O76094: TM-score 0.95, RMSD 1.13 Å
- 5WRV chain B against the predicted model O76094: TM-score 0.95, RMSD 1.13 Å
- 5M72 chain A against the predicted model O76094: TM-score 0.94, RMSD 1.25 Å
- 5M72 chain A against the predicted model O76094: TM-score 0.94, RMSD 1.25 Å
- 8QVW chain B against the predicted model O76094: TM-score 0.91, RMSD 2.27 Å
- 8QVX chain B against the predicted model O76094: TM-score 0.89, RMSD 2.68 Å
- 5M73 chain D against the predicted model O76094: TM-score 0.45, RMSD 2.82 Å
- 5M73 chain D against the predicted model O76094: TM-score 0.45, RMSD 2.82 Å
Elsewhere
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