Structure of the human SRP68-72 protein-binding domain complex

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).

Ligands and binding sites

• K · Potassium ion · metal · chains A
• SO4 · Sulfate ion · ion · 2 copies · chains A
• GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1231 Ų buried · 11 hydrogen bonds · protein-protein

Compared structures

• 5M72 · Structure of the human SRP68-72 protein-binding domain complex · the same entry in another collection · chain A against A, TM-score 1.00
• O76094 · AlphaFold monomer V2.0 prediction for signal recognition particle subunit SRP72 (O76094) · a predicted model of the same protein · chain A against A, TM-score 0.94
• Q9UHB9 · AlphaFold monomer V2.0 prediction for signal recognition particle subunit SRP68 (Q9UHB9) · a predicted model of the same protein · chain B against A, TM-score 0.59

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O76094
• Every structure of UniProt Q9UHB9
• Elsewhere: RCSB PDB 5M72 · PDBe 5M72 · UniProt O76094 · UniProt Q9UHB9