MolNFT v1 · #138523 · protein
Crystal structure of the human mitochondrial cysteine desulfurase with active cysteine loop within ISCU1 active site, coordinating zn ion. complexed with human ISD11 and E. COLI ACP1 at 3.3A.
5WLW: “Crystal structure of the human mitochondrial cysteine desulfurase with active cysteine loop within ISCU1…”. X-ray diffraction, 3 ligands (PLP, 8Q1, ZN). MolNFT v1 #138523 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5WLW
- Type
- protein
- Length
- 1,357 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9Y697, Q9HD34, B7MJ81, Q9H1K1
- Ligands
- PLP, 8Q1, ZN
Structure
x-ray diffraction · 8 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 399 | — | Q9Y697 |
| B | — | protein | 81 | — | Q9HD34 |
| C | — | protein | 71 | — | B7MJ81 |
| D | — | protein | 128 | — | Q9H1K1 |
| E | — | protein | 401 | — | Q9Y697 |
| F | — | protein | 83 | — | Q9HD34 |
| G | — | protein | 70 | — | B7MJ81 |
| H | — | protein | 124 | — | Q9H1K1 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, E
- 8Q1 · S-[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy) butanoyl]-beta-alanyl}amino)ethyl] dodecanethioate · ligand · 2 copies · chains B, C, F, G
- ZN · Zinc ion · metal · 2 copies · chains A, D, E, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5WLW · Crystal Structure of the Human Mitochondrial Cysteine Desulfurase with active Cysteine… · the same entry in another collection · chain H against H, TM-score 1.00
- Q9Y697 · AlphaFold monomer V2.0 prediction for cysteine desulfurase, mitochondrial (Q9Y697) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9HD34 · AlphaFold monomer V2.0 prediction for lyr motif-containing protein 4 (Q9HD34) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y697
- Every structure of UniProt Q9HD34
- Every structure of UniProt B7MJ81
- Every structure of UniProt Q9H1K1
- Elsewhere: RCSB PDB 5WLW · PDBe 5WLW · UniProt Q9Y697 · UniProt Q9HD34 · UniProt B7MJ81 · UniProt Q9H1K1
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