Human POGLUT1 in complex with human NOTCH1 EGF12 S458T mutant and udp

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 17% strand (DSSP).

Ligands and binding sites

• UDP · Uridine-5'-diphosphate · ligand · chains A
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 3 copies · chains A
• CA · Calcium ion · metal · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 823 Ų buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 7 disulfide, 3 glycan (disulfide, N-glycosylation).

Compared structures

• 5UB5 · human POGLUT1 in complex with human Notch1 EGF12 S458T mutant and UDP · the same entry in another collection · chain A against A, TM-score 1.00
• Q8NBL1 · AlphaFold monomer V2.0 prediction for protein O-glucosyltransferase 1 (Q8NBL1) · a predicted model of the same protein · chain A against A, TM-score 1.00
• P46531 · AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 1 (P46531) · a predicted model of the same protein · chain B against A, TM-score 0.83

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8NBL1
• Every structure of UniProt P46531
• Elsewhere: RCSB PDB 5UB5 · PDBe 5UB5 · UniProt Q8NBL1 · UniProt P46531