MolNFT v1 · #134916 · protein
CA2+ bound aplysia SLO1
5TJ6 · High conductance calcium-activated potassium channel: “CA2+ bound aplysia SLO1”. Electron microscopy, 4 ligands (PGW, K, CA), 13 pockets (best druggability 0.74). MolNFT v1 #134916 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5TJ6
- Type
- protein
- Length
- 890 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- High conductance calcium-activated potassium channel
- UniProt
- Q5QJC5
- Ligands
- PGW, K, CA, MG
- Pockets
- 13 · best druggability 0.74
Structure
electron microscopy · 1 distinct chain · 48% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | High conductance calcium-activated potassium channel | protein | 890 | 48% helix, 14% strand | Q5QJC5 |
Ligands and binding sites
- PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · ligand · 15 copies · chains A
- K · Potassium ion · metal · 5 copies · chains A
- CA · Calcium ion · metal · 2 copies · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 129 | 0.74 | 0.93 | 21 | empty |
| 2 | 428 | 0.66 | 0.79 | 59 | empty |
| 3 | 321 | 0.60 | 0.78 | 38 | empty |
| 4 | 194 | 0.56 | 0.80 | 25 | empty |
| 5 | 171 | 0.56 | 0.80 | 23 | empty |
Compared structures
- 5TJ6 · Ca2+ bound aplysia Slo1 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5QJC5
- Elsewhere: RCSB PDB 5TJ6 · PDBe 5TJ6 · UniProt Q5QJC5
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