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CA2+ bound aplysia SLO1

Analyse CA2+ bound aplysia SLO1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5TJ6
Type: protein
Length: 890 residues
Chains: 1
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: High conductance calcium-activated potassium channel
UniProt: Q5QJC5
Ligands: PGW, K, CA, MG
Pockets: 13 · best druggability 0.74

Structure

electron microscopy · 1 distinct chain · 48% helix, 14% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	High conductance calcium-activated potassium channel	protein	890	48% helix, 14% strand	Q5QJC5

Ligands and binding sites

PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · ligand · 15 copies · chains A
K · Potassium ion · metal · 5 copies · chains A
CA · Calcium ion · metal · 2 copies · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	129	0.74	0.93	21	empty
2	428	0.66	0.79	59	empty
3	321	0.60	0.78	38	empty
4	194	0.56	0.80	25	empty
5	171	0.56	0.80	23	empty

Compared structures

5TJ6 · Ca2+ bound aplysia Slo1 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5QJC5
Elsewhere: RCSB PDB 5TJ6 · PDBe 5TJ6 · UniProt Q5QJC5

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