Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate and BRD4592-bound form

Structure

x-ray diffraction · 6 distinct chains.

Ligands and binding sites

• 79V · (2R,3S,4R)-3-(2'-fluoro[1,1'-biphenyl]-4-yl)-4-(hydroxymethyl)azetidine-2-carbonitrile · ligand · 4 copies · chains A, B, G, H, E, F, C, D
• CS · Cesium ion · metal · 9 copies · chains B, D, H, F
• FMT · Formic acid · additive · 22 copies · chains A, B, D, G, H, F, E, C
• MLI · Malonate ion · additive · 4 copies · chains A, G, E, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5TCJ · Crystal structure of tryptophan synthase from M. tuberculosis - aminoacrylate and… · the same entry in another collection · chain G against G, TM-score 1.00
• P9WFY1 · AlphaFold monomer V2.0 prediction for tryptophan synthase alpha chain (P9WFY1) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P9WFY1
• Every structure of UniProt P9WFX9
• Elsewhere: RCSB PDB 5TCJ · PDBe 5TCJ · UniProt P9WFY1 · UniProt P9WFX9