MolNFT v1 · #134580 · protein
P110DELTA/P85ALPHA with taselisib (gdc-0032)
5T8F: “P110DELTA/P85ALPHA with taselisib (gdc-0032)”. X-ray diffraction, 1 ligand (799). MolNFT v1 #134580 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5T8F
- Type
- protein
- Length
- 1,090 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O00329, P23727
- Ligands
- 799
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 921 | — | O00329 |
| B | — | protein | 169 | — | P23727 |
Ligands and binding sites
- 799 · 2-methyl-2-(4-{2-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-D][1, 4]benzoxazepin-9-yl}-1H-pyrazol-1-yl)propanamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5T8F · p110delta/p85alpha with taselisib (GDC-0032) · the same entry in another collection · chain A against A, TM-score 1.00
- O00329 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase… · a predicted model of the same protein · chain A against A, TM-score 0.98
- P23727 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 3-kinase regulatory subunit… · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00329
- Every structure of UniProt P23727
- Elsewhere: RCSB PDB 5T8F · PDBe 5T8F · UniProt O00329 · UniProt P23727
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