MolNFT v1 · #300422 · protein
AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (O00329)
O00329: “AlphaFold monomer V2.0 prediction for phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta…”. 12 pockets (best druggability 0.84). MolNFT v1 #300422 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- O00329
- Type
- protein
- Length
- 1,044 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x025f3b1a898b05AD2731bE6Ab72687b5920c4A3F
- Molecule
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
- UniProt
- O00329
- Pockets
- 12 · best druggability 0.84
Structure
1 distinct chain · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | protein | 1044 | 43% helix, 18% strand | O00329 |
Pockets
12 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1112 | 0.84 | 0.85 | 102 | empty |
| 2 | 950 | 0.73 | 0.77 | 77 | empty |
| 3 | 662 | 0.68 | 0.76 | 56 | empty |
| 4 | 232 | 0.65 | 0.83 | 37 | empty |
| 5 | 330 | 0.63 | 0.79 | 37 | empty |
Compared structures
- 7LQ1 · Human PI3KDELTA in complex with compound 28 · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 7LQ1 · Human PI3KDELTA in complex with compound 28 · an experimental structure of the same protein · chain A against A, TM-score 0.89
- 7LM2 · Human PI3KDELTA in complex with compound 3C · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 7LM2 · Human PI3KDELTA in complex with compound 3C · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 6PYR · Human PI3KDELTA in complex with compound 2-10 ((3S)-3-benzyl-3-methyl… · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 6PYR · Human PI3Kdelta in complex with Compound 2-10 ((3S)-3-benzyl-3-methyl-5-[5-(2-methylpyrimi… · an experimental structure of the same protein · chain A against A, TM-score 0.88
- 9GDI · Human PI3KDELTA in complex with isocumarin inhibitor 10 · an experimental structure of the same protein · chain A against A, TM-score 0.87
- 6OCO · Human PI3KDELTA in complex with compound 6 · an experimental structure of the same protein · chain A against A, TM-score 0.87
- 6OCO · Human PI3KDELTA in complex with compound 6 · an experimental structure of the same protein · chain A against A, TM-score 0.87
- 6PYU · Human PI3KDELTA in complex with compound 4-2 ((3S)-1'… · an experimental structure of the same protein · chain A against A, TM-score 0.87
- 6PYU · Human PI3Kdelta in complex with Compound 4-2 ((3S)-1'-(cyclopropanecarbonyl)-5-(quinoxalin… · an experimental structure of the same protein · chain A against A, TM-score 0.87
- 6G6W · Human PI3KDELTA in complex with ligand LASW1976 · an experimental structure of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00329
- Elsewhere: UniProt O00329 · AlphaFold DB O00329
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