UniProt P23727
Phosphatidylinositol 3-kinase regulatory subunit alpha (P23727)
Phosphatidylinositol 3-kinase regulatory subunit alpha (UniProt P23727): 39 experimental structures on GenesisL1, 1 ligand bound, 3 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P23727
- Protein
- Phosphatidylinositol 3-kinase regulatory subunit alpha
- Experimental structures
- 39
- Predicted models
- 0
- Ligands
- 1
- Pockets
- 3 · 2 records with a druggable one
Structures
39 records of P23727 in the MolNFT archive: 39 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1BFI | Solution structure of the C-terminal SH2 domain of the P85ALPHA regulatory subunit of… | solution nmr | A | — | — |
| 1BFI | Solution structure of the C-terminal SH2 domain of the P85ALPHA regulatory subunit of… | solution nmr | A | — | — |
| 1BFJ | Solution structure of the C-terminal SH2 domain of the P85ALPHA regulatory subunit of… | solution nmr | A | — | — |
| 1BFJ | Solution structure of the C-terminal SH2 domain of the P85ALPHA regulatory subunit of… | solution nmr | A | — | — |
| 1OO3 | P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase | solution nmr | A | — | — |
| 1OO3 | P395S mutant of the P85 regulatory subunit of the N-terminal src homology 2 domain of PI3-kinase | solution nmr | A | — | — |
| 1OO4 | P395S mutant of the p85 regulatory subunit of the N-terminal src homology 2 domain of PI3-Kinase… | solution nmr | A | — | — |
| 1OO4 | P395S mutant of the P85 regulatory subunit of the N-terminal src homology 2 domain of PI3-kinase… | solution nmr | A | — | — |
| 1PNJ | Solution structure and ligand-binding site of the SH3 domain of the P85ALPHA subunit of… | solution nmr | A | — | — |
| 1PNJ | Solution structure and ligand-binding site of the SH3 domain of the P85ALPHA subunit of… | solution nmr | A | — | — |
| 1QAD | Crystal Structure of the C-Terminal SH2 Domain of the P85 alpha Regulatory Subunit of… | x-ray diffraction | A | — | — |
| 1QAD | Crystal structure of the C-terminal SH2 domain of the P85 alpha regulatory subunit of… | x-ray diffraction | A | — | — |
| 2PNA | Structure of an SH2 domain of the P85 alpha subunit of phosphatidylinositol-3-oh kinase | solution nmr | A | — | — |
| 2PNA | Structure of an SH2 domain of the P85 alpha subunit of phosphatidylinositol-3-oh kinase | solution nmr | A | — | — |
| 2PNB | Structure of an SH2 domain of the P85 alpha subunit of phosphatidylinositol-3-oh kinase | solution nmr | A | — | — |
| 2PNB | Structure of an SH2 domain of the P85 alpha subunit of phosphatidylinositol-3-oh kinase | solution nmr | A | — | — |
| 2PNI | Solution structure and ligand-binding site of the SH3 domain of the P85ALPHA subunit of… | solution nmr | A | — | — |
| 2PNI | Solution structure and ligand-binding site of the SH3 domain of the P85ALPHA subunit of… | solution nmr | A | — | — |
| 5DXH | p110alpha/p85alpha with compound 5 | x-ray diffraction | B, E | — | — |
| 5DXH | P110ALPHA/P85ALPHA with compound 5 | x-ray diffraction | B, E | — | — |
| 5DXU | p110delta/p85alpha with GDC-0326 | x-ray diffraction | B | — | 1 (best 0.83) |
| 5DXU | P110DELTA/P85ALPHA with gdc-0326 | x-ray diffraction | B | — | — |
| 5T8F | p110delta/p85alpha with taselisib (GDC-0032) | x-ray diffraction | B | — | 1 (best 0.82) |
| 5T8F | P110DELTA/P85ALPHA with taselisib (gdc-0032) | x-ray diffraction | B | — | — |
| 6D81 | Structure of the bovine P85A bh domain | x-ray diffraction | A, B | SO4 | — |
| 6D82 | Structure of the bovine P85A bh domain | x-ray diffraction | B, A | SO4 | — |
| 6D85 | Structure of the bovine P85A bh domain E217K mutant | x-ray diffraction | B, A | SO4 | — |
| 6D86 | Structure of the bovine P85A bh domain | x-ray diffraction | B, A | SO4 | — |
| 6D87 | Structure of the Bovine p85alpha BH domain, R262T mutant | x-ray diffraction | B, A | SO4 | 1 (best 0.44) |
| 6D87 | Structure of the bovine P85ALPHA bh domain, R262T mutant | x-ray diffraction | B, A | SO4 | — |
| 6G6W | Human PI3KDELTA in complex with ligand LASW1976 | x-ray diffraction | B | — | — |
| 6MRP | Structure of the Bovine p85a BH domain R228E mutant | x-ray diffraction | B, A | — | — |
| 6MRP | Structure of the bovine P85A bh domain R228E mutant | x-ray diffraction | B, A | — | — |
| 6OCO | Human PI3KDELTA in complex with compound 6 | x-ray diffraction | B | — | — |
| 6OCU | Human PI3KDELTA in complex with compound 29 | x-ray diffraction | B | — | — |
| 6R4R | Cryo-EM structure of the PI3-kinase SH3 domain amyloid fibril | electron microscopy | A, B, C, D, E, F, G | — | — |
| 7JIS | Human PI3KDELTA in complex with compound 2F | x-ray diffraction | B | — | — |
| 7JIS | Human PI3KDELTA in complex with compound 2F | x-ray diffraction | B | — | — |
| P23727 | AlphaFold monomer V2.0 prediction for phosphatidylinositol 3-kinase regulatory subunit alpha… | — | — | — |
Ligands
- SO4 · Sulfate ion · in 6 records
Elsewhere
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