MolNFT v1 · #1299 · protein
Structural plasticity at the HGH:HGHBP interface
1AXI · Growth hormone: “Structural plasticity at the HGH:HGHBP interface”. X-ray diffraction, 1 ligand (SO4), 5 pockets (best druggability 0.71). MolNFT v1 #1299 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1AXI
- Type
- protein
- Length
- 366 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Growth hormone; Growth hormone receptor
- UniProt
- P01241, P10912
- Ligands
- SO4
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 37% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Growth hormone | protein | 175 | 73% helix, 0% strand | P01241 |
| B | Growth hormone receptor | protein | 191 | 4% helix, 47% strand | P10912 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.71 | 0.98 | 17 | empty |
| 2 | 139 | 0.44 | 0.76 | 25 | empty |
| 3 | 140 | 0.41 | 0.74 | 22 | empty |
| 4 | 55 | 0.38 | 0.81 | 17 | empty |
| 5 | 51 | 0.30 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1347 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- 1AXI · Structural plasticity at the HGH:HGHBP interface · the same entry in another collection · chain A against A, TM-score 1.00
- P10912 · AlphaFold monomer V2.0 prediction for growth hormone receptor (P10912) · a predicted model of the same protein · chain B against A, TM-score 0.97
- P01241 · AlphaFold monomer V2.0 prediction for somatotropin (P01241) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01241
- Every structure of UniProt P10912
- Elsewhere: RCSB PDB 1AXI · PDBe 1AXI · UniProt P01241 · UniProt P10912
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.