Pseudo-atomic model of microtubule-bound S.POMBE kinesin-5 motor domain in the amppnp state (based on cryo-electron microscopy experiment): the N-terminus conformation allows formation of a cover neck bundle.

Structure

electron microscopy · 3 distinct chains.

Ligands and binding sites

• GTP · Guanosine-5'-triphosphate · ligand
• GDP · Guanosine-5'-diphosphate · ligand · chains B
• TA1 · Taxol · ligand · chains B
• ANP · Phosphoaminophosphonic acid-adenylate ester · ligand · chains C
• MG · Magnesium ion · metal · 2 copies · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5M5I · Pseudo-atomic model of microtubule-bound S.pombe kinesin-5 motor domain in the AMPPNP… · the same entry in another collection · chain A against A, TM-score 1.00
• P24339 · AlphaFold monomer V2.0 prediction for kinesin-like protein CUT7 (P24339) · a predicted model of the same protein · chain C against A, TM-score 0.85

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q2HJ86
• Every structure of UniProt Q6B856
• Every structure of UniProt P24339
• Elsewhere: RCSB PDB 5M5I · PDBe 5M5I · UniProt Q2HJ86 · UniProt Q6B856 · UniProt P24339