MolNFT v1 · #126406 · protein

Rarg mutant-S371E

5M24 · Retinoic acid receptor gamma: “Rarg mutant-S371E”. X-ray diffraction, 3 ligands (9CR, LMU, CL), 3 pockets (best druggability 0.81). MolNFT v1 #126406 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5M24
Type: protein
Length: 236 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Retinoic acid receptor gamma
UniProt: P13631
Ligands: 9CR, LMU, CL
Pockets: 3 · best druggability 0.81

Structure

x-ray diffraction · 1 distinct chain · 67% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Retinoic acid receptor gamma	protein	236	67% helix, 4% strand	P13631

Ligands and binding sites

9CR · (9cis)-retinoic acid · ligand · chains A
LMU · Dodecyl-alpha-D-maltoside · ligand · chains A
CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	206	0.81	0.94	34	9CR
2	93	0.42	0.78	18	empty
3	87	0.42	0.78	14	empty

Compared structures

5M24 · RARg mutant-S371E · the same entry in another collection · chain A against A, TM-score 1.00
P13631 · AlphaFold monomer V2.0 prediction for retinoic acid receptor gamma (P13631) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13631
Elsewhere: RCSB PDB 5M24 · PDBe 5M24 · UniProt P13631

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