MolNFT v1 · #122148 · protein

Crystal structure of the second bromodomain of human TAF1L in complex with bromosporine (bsp)

5IGL · Transcription initiation factor tfiid subunit 1-like: “Crystal structure of the second bromodomain of human TAF1L in complex with bromosporine (bsp)”. X-ray diffraction, 1 ligand (BMF), 2 pockets (best druggability 0.52). MolNFT v1…

PDB: 5IGL
Type: protein
Length: 139 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription initiation factor tfiid subunit 1-like
UniProt: Q8IZX4
Ligands: BMF
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription initiation factor tfiid subunit 1-like	protein	139	75% helix, 0% strand	Q8IZX4

Ligands and binding sites

BMF · Bromosporine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.52	0.84	20	BMF
2	69	0.36	0.77	14	empty

Compared structures

5IGL · Crystal structure of the second bromodomain of human TAF1L in complex with bromosporine… · the same entry in another collection · chain A against A, TM-score 1.00
Q8IZX4 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit… · a predicted model of the same protein · chain A against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IZX4
Elsewhere: RCSB PDB 5IGL · PDBe 5IGL · UniProt Q8IZX4

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