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Crystal structure of the second bromodomain of human TAF1L in complex with bromosporine (bsp)

Analyse Crystal structure of the second bromodomain of human TAF1L in complex with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5IGL
Type: protein
Length: 139 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcription initiation factor tfiid subunit 1-like
UniProt: Q8IZX4
Ligands: BMF
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 75% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcription initiation factor tfiid subunit 1-like	protein	139	75% helix, 0% strand	Q8IZX4

Ligands and binding sites

BMF · Bromosporine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.52	0.84	20	BMF
2	69	0.36	0.77	14	empty

Compared structures

5IGL · Crystal structure of the second bromodomain of human TAF1L in complex with bromosporine… · the same entry in another collection · chain A against A, TM-score 1.00
Q8IZX4 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit… · a predicted model of the same protein · chain A against A, TM-score 0.76

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IZX4
Elsewhere: RCSB PDB 5IGL · PDBe 5IGL · UniProt Q8IZX4

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