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Ligand · BMF

BMF · Bromosporine

BMF, Bromosporine (C17 H20 N6 O4 S, 404.4 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (11 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found with it.

Component
BMF
Formula
C17 H20 N6 O4 S
Class
ligand
Structures
12
PDB entries
11

Binding sites

BMF in 12 structures; the first of them:

  • 5CZG · Crystal Structure Analysis of hypothetical bromodomain Tb427.10.7420 from Trypanosoma… · BMF A503 · binds MET30, VAL35, LEU40, TYR43, ALA82, TYR85, ASN86, TRP92
  • 5U9N · Second Bromodomain of cdg4_1340 from Cryptosporidium parvum, complexed with bromosporine · BMF A501 · binds PHE326, LEU327, ASN330, PRO331, VAL332, SER335, ASP337, LEU338 and 4 more
  • 5TCK · Second bromodomain from leishmania donovani LDBPK.091320 complexed with bromosporine · BMF A401 · binds ASN257, SER262, TRP263, LEU266, GLU181, ASP182, GLY183, ALA185 and 1 more
  • 5U9N · Second bromodomain of CDG4_1340 from cryptosporidium parvum, complexed with bromosporine · BMF A501 · binds PHE326, LEU327, ASN330, PRO331, VAL332, SER335, ASP337, LEU338 and 4 more
  • 6NIM · Trypanosoma cruzi - BDF2, TCCLB.506553.20, solved with bromosporine · BMF B201 · binds LEU28, LYS29, MET30, ILE35, LEU40, TYR85, ASN86, GLU91 and 1 more
  • 6V0U · Crystal structure of the first bromodomain (BD1) of human BRD4 bound to bromosporine · BMF A201 · binds TRP81, PRO82, PHE83, GLN85, PRO86, VAL87, ASP88, LYS91 and 6 more
  • 6V1H · Crystal structure of the bromodomain of human BRD7 bound to bromosporine · BMF A301 · binds ALA154, PHE155, PHE156, SER157, PHE158, PRO159, VAL160, ILE164 and 6 more
  • 7K1P · Crystal structure of the second bromodomain (BD2) of human TAF1 bound to bromosporine · BMF A1701 · binds TRP1526, PRO1527, PHE1528, HIS1530, PRO1531, VAL1532, ASN1533, PHE1536 and 4 more
  • 7L6D · Crystal structure of the second bromodomain (BD2) of human BRD2 bound to bromosporine · BMF A501 · binds TRP370, PRO371, PHE372, LYS374, PRO375, VAL376, ASP377, LEU381 and 5 more
  • 7LAH · Crystal structure of the first bromodomain (BD1) of human BRD2 bound to bromosporine · BMF A201 · binds TRP97, PRO98, PHE99, GLN101, PRO102, VAL103, ASP104, LYS107 and 5 more
  • 7LB4 · Crystal structure of the second bromodomain (BD2) of human BRD3 bound to bromosporine · BMF A501 · binds TRP332, PRO333, PHE334, LYS336, PRO337, VAL338, ASP339, LEU343 and 5 more
  • 7LEL · Crystal structure of the second bromodomain (BD2) of human brdt bound to bromosporine · BMF A401 · binds TRP293, PRO294, PHE295, ASN297, PRO298, VAL299, ASP300, LEU304 and 6 more

Residues it binds most

ASN 19, LEU 17, PRO 13, VAL 17, PHE 16, ASP 15, TRP 16, TYR 9, CYS 12, SER 9 (residue and the binding sites it lines).

Found with

  • EDO · 1,2-ethanediol
  • SO4 · Sulfate ion
  • UNX · Unknown atom or ion
  • SX · Sulfur oxide
  • NA · Sodium ion
  • PO4 · Phosphate ion
  • BME · Beta-mercaptoethanol

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