MolNFT v1 · #119387 · protein

Crystal structure of mus musculus protein arginine methyltransferase 2 with sah

5FUL · Protein arginine N-methyltransferase 2: “Crystal structure of mus musculus protein arginine methyltransferase 2 with sah”. X-ray diffraction, 3 ligands (SAH, CA, CL), 2 pockets (best druggability 0.74). MolNFT v1 #119387 on…

PDB: 5FUL
Type: protein
Length: 339 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein arginine N-methyltransferase 2
EC: 2.1.1.125
UniProt: Q3UKX1
Ligands: SAH, CA, CL
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 28% helix, 36% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein arginine N-methyltransferase 2 (EC 2.1.1.125)	protein	339	28% helix, 36% strand	Q3UKX1

Ligands and binding sites

SAH · S-adenosyl-L-homocysteine · ligand · chains A
CA · Calcium ion · metal · 2 copies · chains A
CL · Chloride ion · ion · chains A
EDO · 1,2-ethanediol · additive · 2 copies · chains A
PG4 · Tetraethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	403	0.74	0.84	50	SAH, CA, EDO
2	52	0.27	0.74	16	CL

Compared structures

5FUL · Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with SAH · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt Q3UKX1
Elsewhere: RCSB PDB 5FUL · PDBe 5FUL · UniProt Q3UKX1

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