MolNFT v1 · #112333 · protein
Yoph W354H yersinia enterocolitica ptpase bond with divanadate glycerol ester in the active site
4ZI4 · Tyrosine-protein phosphatase yoph: “Yoph W354H yersinia enterocolitica ptpase bond with divanadate glycerol ester in the active site”. X-ray diffraction, 2 ligands (DVG, VO4), 2 pockets (best druggability 0.55). MolNFT v1 #112333 on…
- PDB
- 4ZI4
- Type
- protein
- Length
- 282 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase yoph
- EC
- 3.1.3.48
- UniProt
- P15273
- Ligands
- DVG, VO4
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase yoph (EC 3.1.3.48) | protein | 282 | 38% helix, 20% strand | P15273 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.55 | 0.82 | 27 | DVG |
| 2 | 120 | 0.42 | 0.77 | 20 | empty |
Compared structures
- 4ZI4 · YopH W354H Yersinia enterocolitica PTPase bond with Divanadate glycerol ester in the… · the same entry in another collection · chain A against A, TM-score 1.00
- P15273 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase yoph (P15273) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15273
- Elsewhere: RCSB PDB 4ZI4 · PDBe 4ZI4 · UniProt P15273
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