Research workbench
Yoph W354H yersinia enterocolitica ptpase bond with divanadate glycerol ester in the active site
Analyse Yoph W354H yersinia enterocolitica ptpase bond with divanadate glycerol ester… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZI4
- Type
- protein
- Length
- 282 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase yoph
- EC
- 3.1.3.48
- UniProt
- P15273
- Ligands
- DVG, VO4
- Pockets
- 2 · best druggability 0.55
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase yoph (EC 3.1.3.48) | protein | 282 | 38% helix, 20% strand | P15273 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.55 | 0.82 | 27 | DVG |
| 2 | 120 | 0.42 | 0.77 | 20 | empty |
Compared structures
- 4ZI4 · YopH W354H Yersinia enterocolitica PTPase bond with Divanadate glycerol ester in the… · the same entry in another collection · chain A against A, TM-score 1.00
- P15273 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase yoph (P15273) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15273
- Elsewhere: RCSB PDB 4ZI4 · PDBe 4ZI4 · UniProt P15273
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