MolNFT v1 · #106476 · protein
Crystal structure of PTPN3 (PTPH1) in complex with EPS15 PTYR849 P850V peptide
4S0G · Tyrosine-protein phosphatase non-receptor type 3: “Crystal structure of PTPN3 (PTPH1) in complex with EPS15 PTYR849 P850V peptide”. X-ray diffraction, 2 pockets (best druggability 0.37). MolNFT v1 #106476 on GenesisL1: 3D structure…
- PDB
- 4S0G
- Type
- protein
- Length
- 285 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 3; Peptide from epidermal growth factor…
- EC
- 3.1.3.48
- UniProt
- P26045, P42566
- Pockets
- 2 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) | protein | 279 | 36% helix, 23% strand | P26045 |
| B | Peptide from epidermal growth factor receptor substrate 15 | protein | 6 | 0% helix, 0% strand | P42566 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.37 | 0.78 | 16 | empty |
| 2 | 57 | 0.36 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 467 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 4S0G · Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 P850V peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P26045 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 3… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P42566 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor substrate 15… · a predicted model of the same protein · chain B against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26045
- Every structure of UniProt P42566
- Elsewhere: RCSB PDB 4S0G · PDBe 4S0G · UniProt P26045 · UniProt P42566
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