Research workbench
Crystal structure of PTPN3 (PTPH1) in complex with EPS15 PTYR849 P850V peptide
Analyse Crystal structure of PTPN3 (PTPH1) in complex with EPS15 PTYR849 P850V peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4S0G
- Type
- protein
- Length
- 285 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 3; Peptide from epidermal growth factor…
- EC
- 3.1.3.48
- UniProt
- P26045, P42566
- Pockets
- 2 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) | protein | 279 | 36% helix, 23% strand | P26045 |
| B | Peptide from epidermal growth factor receptor substrate 15 | protein | 6 | 0% helix, 0% strand | P42566 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 64 | 0.37 | 0.78 | 16 | empty |
| 2 | 57 | 0.36 | 0.78 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 467 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 4S0G · Crystal structure of PTPN3 (PTPH1) in complex with Eps15 pTyr849 P850V peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P26045 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 3… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P42566 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor substrate 15… · a predicted model of the same protein · chain B against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P26045
- Every structure of UniProt P42566
- Elsewhere: RCSB PDB 4S0G · PDBe 4S0G · UniProt P26045 · UniProt P42566
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