MolNFT v1 · #104161 · protein
WNK1: a chloride sensor via autophosphorylation
4Q2A · SERINE/THREONINE-protein kinase WNK1: “WNK1: a chloride sensor via autophosphorylation”. X-ray diffraction, 1 ligand (BR), 2 pockets (best druggability 0.76). MolNFT v1 #104161 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 4Q2A
- Type
- protein
- Length
- 271 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SERINE/THREONINE-protein kinase WNK1
- EC
- 2.7.11.1
- UniProt
- Q9JIH7
- Ligands
- BR
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase WNK1 (EC 2.7.11.1) | protein | 271 | 37% helix, 21% strand | Q9JIH7 |
Ligands and binding sites
- BR · Bromide ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 785 | 0.76 | 0.80 | 76 | BR |
| 2 | 72 | 0.39 | 0.79 | 17 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9JIH7
- Elsewhere: RCSB PDB 4Q2A · PDBe 4Q2A · UniProt Q9JIH7
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