Research workbench

WNK1: a chloride sensor via autophosphorylation

Analyse WNK1: a chloride sensor via autophosphorylation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4Q2A
Type: protein
Length: 271 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase WNK1
EC: 2.7.11.1
UniProt: Q9JIH7
Ligands: BR
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase WNK1 (EC 2.7.11.1)	protein	271	37% helix, 21% strand	Q9JIH7

Ligands and binding sites

BR · Bromide ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	785	0.76	0.80	76	BR
2	72	0.39	0.79	17	empty

Compared structures

4Q2A · WNK1: A chloride sensor via autophosphorylation · the same entry in another collection · chain A against A, TM-score 1.00
Q9JIH7 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK1 (Q9JIH7) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9JIH7
Elsewhere: RCSB PDB 4Q2A · PDBe 4Q2A · UniProt Q9JIH7

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