UniProt Q9JIH7
Serine/threonine-protein kinase WNK1 (Q9JIH7)
Serine/threonine-protein kinase WNK1 (UniProt Q9JIH7), EC 2.7.11.1: 14 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 23 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9JIH7
- Protein
- Serine/threonine-protein kinase WNK1
- EC
- 2.7.11.1
- Experimental structures
- 14
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 23 · 6 records with a druggable one
Structures
15 records of Q9JIH7 in the MolNFT archive: 14 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2LRU | Solution Structure of the WNK1 Autoinhibitory Domain | solution nmr | A | — | — |
| 2LRU | Solution structure of the WNK1 autoinhibitory domain | solution nmr | A | — | — |
| 4Q2A | WNK1: A chloride sensor via autophosphorylation | x-ray diffraction | A | — | — |
| 4Q2A | WNK1: a chloride sensor via autophosphorylation | x-ray diffraction | A | — | — |
| 5DRB | Crystal structure of WNK1 in complex with WNK463 | x-ray diffraction | A | 5FJ | — |
| 5DRB | Crystal structure of WNK1 in complex with WNK463 | x-ray diffraction | A | — | — |
| 5W7T | Structure of phosphorylated WNK1 | x-ray diffraction | A, B | ANP | 3 (best 0.65) |
| 5W7T | Structure of phosphorylated WNK1 | x-ray diffraction | A, B | ANP | — |
| 6CN9 | Crystal structure of the Kinase domain of WNK1 | x-ray diffraction | A, B | SO4 | 7 (best 0.79) |
| 6CN9 | Crystal structure of the kinase domain of WNK1 | x-ray diffraction | A, B | SO4 | — |
| 6OL2 | Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening | x-ray diffraction | A | MU7 | 2 (best 0.81) |
| 6OL2 | Crystallography of novel WNK1 and WNK3 inhibitors discovered from high-throughput-screening | x-ray diffraction | A | MU7 | — |
| 7UOS | Structure of WNK1 inhibitor complex | x-ray diffraction | A | WIB | 3 (best 0.67) |
| 9D3F | Water and chloride as allosteric inhibitors in WNK kinase osmosensing | x-ray diffraction | A | — | 3 (best 0.63) |
| Q9JIH7 | AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK1 (Q9JIH7) | predicted | A | — | 5 (best 0.76) |
Ligands
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- MU7 · N-[2-(5,8-dimethoxy-2-oxo-1,2-dihydroquinolin-3-yl) ethyl]-2-iodobenzamide · in 2 records
- SO4 · Sulfate ion · in 2 records
- 5FJ · N-tert-butyl-1-(1-{5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridin-2-yl}piperidin-4-yl)-1H-imidazole-5-carboxamide · in 1 record
- WIB · 4-[bromo(dichloro)methanesulfonyl]-N-cyclohexyl-2-nitroaniline · in 1 record
Experiment against prediction
- 5W7T chain B against the predicted model Q9JIH7: TM-score 0.96, RMSD 1.52 Å
- 5W7T chain A against the predicted model Q9JIH7: TM-score 0.94, RMSD 1.33 Å
- 5W7T chain A against the predicted model Q9JIH7: TM-score 0.94, RMSD 1.33 Å
- 9D3F chain A against the predicted model Q9JIH7: TM-score 0.94, RMSD 1.94 Å
- 4Q2A chain A against the predicted model Q9JIH7: TM-score 0.94, RMSD 1.66 Å
- 4Q2A chain A against the predicted model Q9JIH7: TM-score 0.94, RMSD 1.66 Å
- 6CN9 chain A against the predicted model Q9JIH7: TM-score 0.93, RMSD 1.92 Å
- 6CN9 chain A against the predicted model Q9JIH7: TM-score 0.93, RMSD 1.92 Å
- 5DRB chain A against the predicted model Q9JIH7: TM-score 0.93, RMSD 1.90 Å
- 5DRB chain A against the predicted model Q9JIH7: TM-score 0.93, RMSD 1.90 Å
Elsewhere
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