MolNFT v1 · #499953 · protein
AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK1 (Q9JIH7)
Q9JIH7: “AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase WNK1 (Q9JIH7)”. 5 pockets (best druggability 0.76). MolNFT v1 #499953 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9JIH7
- Type
- protein
- Length
- 2,126 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xE1b961cFdddF7335AbA492F1fc32079dEd2c4285
- Molecule
- SERINE/THREONINE-protein kinase WNK1
- UniProt
- Q9JIH7
- Pockets
- 5 · best druggability 0.76
Structure
1 distinct chain · 12% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SERINE/THREONINE-protein kinase WNK1 | protein | 2126 | 12% helix, 5% strand | Q9JIH7 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 699 | 0.76 | 0.81 | 70 | empty |
| 2 | 67 | 0.60 | 0.90 | 20 | empty |
| 3 | 126 | 0.41 | 0.75 | 16 | empty |
| 4 | 89 | 0.35 | 0.74 | 21 | empty |
| 5 | 56 | 0.30 | 0.75 | 12 | empty |
Compared structures
- 5W7T · Structure of phosphorylated WNK1 · an experimental structure of the same protein · chain A against B, TM-score 0.13
- 5W7T · Structure of phosphorylated WNK1 · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 6OL2 · Crystallography of novel WNK1 and WNK3 inhibitors discovered from… · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 6OL2 · Crystallography of novel WNK1 and WNK3 inhibitors discovered from… · an experimental structure of the same protein · chain A against A, TM-score 0.13
- 5DRB · Crystal structure of WNK1 in complex with WNK463 · an experimental structure of the same protein · chain A against A, TM-score 0.12
- 5DRB · Crystal structure of WNK1 in complex with WNK463 · an experimental structure of the same protein · chain A against A, TM-score 0.12
- 7UOS · Structure of WNK1 inhibitor complex · an experimental structure of the same protein · chain A against A, TM-score 0.12
- 6CN9 · Crystal structure of the Kinase domain of WNK1 · an experimental structure of the same protein · chain A against A, TM-score 0.12
- 6CN9 · Crystal structure of the kinase domain of WNK1 · an experimental structure of the same protein · chain A against A, TM-score 0.12
- 4Q2A · WNK1: A chloride sensor via autophosphorylation · an experimental structure of the same protein · chain A against A, TM-score 0.12
- 4Q2A · WNK1: a chloride sensor via autophosphorylation · an experimental structure of the same protein · chain A against A, TM-score 0.12
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9JIH7
- Elsewhere: UniProt Q9JIH7 · AlphaFold DB Q9JIH7
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