MolNFT v1 · #102312 · protein + RNA
Bound to ssrna dinucleotide gc, ADP, ALF4-, and MG2+(TRANSITION state, data set I)
4OI0 · Protein clpf-1: “Bound to ssrna dinucleotide gc, ADP, ALF4-, and MG2+(TRANSITION state, data set I)”. X-ray diffraction, 4 ligands (SAR, ADP, ALF), 4 pockets (best druggability 0.82). MolNFT v1 #102312 on GenesisL1: 3D structure…
- PDB
- 4OI0
- Type
- protein + RNA
- Length
- 398 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein clpf-1; RNA (5'-R(*GP*C)-3')
- UniProt
- P52874
- Ligands
- SAR, ADP, ALF, MG
- Pockets
- 4 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein clpf-1 | protein | 396 | 28% helix, 33% strand | P52874 |
| B | RNA (5'-R(*GP*C)-3') | rna | 2 | — | — |
Ligands and binding sites
- SAR · Sarcosine · ligand · 2 copies · chains A
- ADP · Adenosine-5'-diphosphate · ligand · chains A, B
- ALF · Tetrafluoroaluminate ion · ligand · chains A, B
- MG · Magnesium ion · metal · chains A, B
- 2PE · Nonaethylene glycol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 966 | 0.82 | 0.83 | 77 | ADP, MG, ALF |
| 2 | 256 | 0.54 | 0.76 | 37 | empty |
| 3 | 56 | 0.42 | 0.82 | 14 | empty |
| 4 | 69 | 0.39 | 0.79 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 337 Ų buried · 11 hydrogen bonds · protein-nucleic
Compared structures
- 4OI0 · bound to ssRNA dinucleotide GC, ADP, AlF4-, and Mg2+(transition state, data set I) · the same entry in another collection · chain A against A, TM-score 1.00
- P52874 · AlphaFold monomer V2.0 prediction for protein clpf-1 (P52874) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52874
- Elsewhere: RCSB PDB 4OI0 · PDBe 4OI0 · UniProt P52874
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